
Weight Loss Medications in OKC
Adipex-P (Phentermine)
Adipex is the brand name of the weight loss medication Phentermine. Phentermine works in weight loss primarily as an appetite suppressant, and secondarily as a stimulant of metabolism. It received FDA approval for weight loss and appetite suppression originally in 1959 and currently ranks as the most popular weight loss medication in the US. Prescriptions of Adipex in OKC also reflect the popularity of this medication for weight loss. Its chemical similarity to the amphetamine class of drugs is responsible for its classification as a Schedule IV drug under the Controlled Substances Act.
The mechanism of action of phentermine is through its stimulation of the hypothalamus portion of the brain to produce norepinephrine, a neurotransmitter or chemical messenger that signals the ‘fight-or-flight’ response, which reduces hunger. Phentermine also works outside the brain to release epinephrine, which causes fat cells to break down stored fat. Phentermine is also thought to release other neurotransmitters, serotonin and dopamine, but to a much lesser extent than norepinephrine.
Phentermine is indicated for the treatment of obesity, but the proper use of this medication is always in concert with diet and exercise. Certain medical conditions or physical states may prohibit the use of phentermine, including pregnancy, hyperthyroidism, atherosclerosis, high blood pressure, high cholesterol and diabetes. Patients having an allergy to phentermine or sympathomimetics (pseudophedrine) and patients taking MAO Inhibitors should not take phentermine.
Bontril
Bontril is the brand name of the weight loss medication Phendimetrazine. The number of prescriptions of Bontril in OKC that are written for weight loss is second only to phentermine. Phendimetrazine functions as an appetite-suppressant and as a stimulant, and is chemically a member of the morpholine family. When taken orally, a portion of the medication is converted to phenmetrazine, which acts as a norepinephrine-dopamine releasing agent in the brain. Pure phenmetrazine is a substance which has the potential for abuse. The phendimetrazine functions as a precursor drug or “prodrug”. Because conversion to phenmetrazine takes time, the medicine acts as if it were an “extended release” medication.
Phendimetrazine is as potent as the amphetamine class of drugs and is classified as Schedule III under the Controlled Substance Act. Other brand names for this medicine include Adipost, Anorex-SR, Appecon, Melfiat and Statobex.
Topamax
Topamax is the brand name of the drug Topiramate. It is in the anticonvulsant family, and Prescriptions for Topamax in OKC are written for the treatment of seizures generally. The chemical structure of Topamax is based on the sugar fructose with a ‘sulfamate’ chemical side group. In addition to its use to treat seizures, Topamax has also been used to treat migraines. It has also been noted to facilitate weight loss, and has been used by psychiatrists to combat the weight gain sometimes seen with psychotropic medications. Recently, a role for the use of Topamax in combination with phentermine in obesity has been proposed followed by testing in clinical trials. The combined medication called Qnexa has been reported to be analogous to the effectiveness of Fen-phen, but without the side effects that led to the removal of Fen-phen from the market. The combination is presently being reviewed by the FDA for safety.
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